Welcome to the Noel Drury, M.D. Institute for Translational Depression Discoveries Transforming our understanding of depression’s origins, treatment, and prevention, while enhancing societal-well being. Learn More about Us

NOW HIRING - Open-Rank Faculty Cluster Hire in Depression Research

Who We Are

Our institute is dedicated to pioneering advancements in understanding, treating, and preventing depression, a prevalent mental health challenge affecting millions. Under the leadership of Dr. Diego A. Pizzagalli, a distinguished expert in mood disorders, we are committed to fostering a collaborative, interdisciplinary environment that spans biology, medicine, engineering, and social sciences. Our mission is to translate scientific breakthroughs into personalized, effective treatments and prevention strategies, enhancing the lives of individuals and communities worldwide. We invite you to join us in this endeavor, as we strive to make significant contributions to mental health research and patient care.

5141 California Ave

Our Research Focus Areas

Mouse Model

Preclinical Models Relevant to Depression

Dna Gel Test

Biomarkers of Depression Risk, Resilience, and Treatment Response

Biomedical Eng

Biomedical Engineering (BME) Solutions to Assess & Treat Depression

close up of female hand with pills in medicine cup

Personalized Treatments and Novel Treatment Strategies

Map Stethescope

Social Determinants of Depression Risk and Maintenance

Young And Old

Depression Across the Lifetime (from Children to Older Adults)

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Institute Leadership

Diego Pizzagalli 2025

Diego A. Pizzagalli,Ph.D.

Amy Ruth

Amy Ruth

Chief Administrative Officer
aruth@uci.edu

280 million

Approximate number of people worldwide (5%) who suffer from depression.

21 million

Number of adults in the U.S. (8.4%) who have experienced a major depressive episode.

10.3%

Prevalence of major depressive episodes among U.S. adult females compared to males (6.2%).

3.7 million

Number of U.S. adolescents aged 12- 17 who had at least one major depressive episode.

700 thousand

Number of suicide deaths every year worldwide. The 4th leading cause of death in 15–29-year-olds.