In the Translational NeuroElectronics Laboratory, we leverage the unique properties of advanced materials to design and develop novel electronic devices that enable efficient interaction with biological substrates, particularly neural networks and the brain. Our work spans the design, fabrication, and characterization of high-performance, biocompatible electronics capable of acquiring and analyzing neural data that are difficult or impossible to obtain using existing technologies. The overarching goal of our research is to translate advances in electronics, materials science, and neuroscience into new discoveries, as well as more effective diagnostic and therapeutic approaches for neuropsychiatric diseases. Our efforts are organized around three thrusts. The first thrust focuses on developing improved neural interfaces by applying electrical engineering and materials science principles to create new device architectures based on organic materials. This talk will primarily focus on this thrust. In the second thrust, we use data collected from these devices to conduct systems neuroscience experiments aimed at dissecting memory circuits. Finally, in close collaboration with dedicated physician colleagues, we work to translate these technological and scientific advances into clinical practice to improve patient care.