Cognitive impairment is common across neuropsychiatric disorders affecting adults and children. It results from complex dysfunction of neural networks and is ineffectively treated with current therapies. This dysfunction can have especially severe consequences in pediatric age group, where neurodevelopment may be irreversibly affected. Therefore, our research program aims to i) elucidate the physiologic mechanisms underlying cognitive processes across the lifespan; ii) develop biomarkers and novel therapeutics for cognitive issues in neuropsychiatric disorders, particularly epilepsy; and iii) leverage advances in materials science, electronics, and neurocomputation to improve care for adult and pediatric patients with these disorders. We use in vivo electrophysiology, behavioral studies, closed-loop technologies, and computational approaches across animal models and human subjects to achieve these goals.