Preclinical Models Relevant to Depression

Our preclinical models research utilizes animal and cellular systems to investigate the fundamental biological mechanisms underlying depression. These models allow us to examine how genetic, molecular, and neural circuit changes contribute to depressive behaviors in controlled laboratory settings. By studying stress responses, reward responsiveness, and other behaviors in experimental animals, we can identify potential therapeutic targets and test novel interventions before human trials. This foundational work includes, for example, assessing neurotransmitter systems, neural plasticity, inflammatory processes, and the impact of early-life adversity on brain development. These preclinical studies are essential for understanding the neurobiological basis of depression and serve as a critical bridge between basic neuroscience and clinical applications.